GREEN-CARE

I am the happy beneficiary of a Horizon Europe grant on the topic ‘towards climate resilient, prepared and carbon neutral populations and healthcare systems’. The project, led by Max Piffoux, is entitled ‘Greening Healthcare Decision-Making and care pathways through Environmental Impact Integration and its Application in Oncology’.

The project will design, prototype and validate an interoperabledecision-support toolbox integrating multi-impact life cycle assessment (LCA) into healthcare innovation and decision-making. It will be applied as a proof-of-concept in oncology, a high-stakes and data-rich specialty. The objectives are to:

  • (i) quantify environmental footprints beyond carbon across care pathways (e.g. drugs release, microparticles, etc)
  • (ii) translate these results into decision-ready indicators with transparent uncertainty
  • (iii) embed these indicators into operational workflows for procurement, clinical trials, health technology assessment (HTA), and care pathway optimisation.

Overview of the work packages and their relations.

I will be responsible for work package 6, described below.

Work package 6: Integrating environmental footprint in clinical trial endpoints

Objectives: Develop, validate and disseminate methods for integrating Environmental footprint and impact in clinical trial statistical design and analyses through composite endpoints and multicriteria analyses.

Timeline: expected to be 2027-2030

The work package is divided into 4 tasks and I will mainly be active in the first two:

  • T6.1: Development of an estimator of time-to-event endpoints adjusted for environmental footprint. Convert pollutant emissions generated along patient care pathways into future health losses (DALYs or life-years lost (YLL)) to create an estimator of time to event endpoints adjusted for environmental footprint.
  • T6.2: Integration of environmental emissions in multicriteria analyses using generalized pairwise comparisons. Will extend the current GPC framework to analyze environmental impact alongside clinical endpoints.
  • T6.3: Application to illustrative examples and dissemination within the medical community
  • T6.4: Development of guidance for investigators on how to integrate environmental emissions in trial designs according to context

Disclaimer

The content of this webpage is heavily inspired and sometimes copy pasted from grant application.